Table 2.
OS Incidence rates, murinegenotypes & its associatedcell lineages
| Cell lineage | Genotype | OS penetrance |
|---|---|---|
| Mesenchymal / Skeletal progenitors |
Prx1-Cre-p53fl/fl |
61% [55]; 62% [56] |
|
Prx1-Cre-p53fl/fl-Rbfl/+ |
92% [56] |
|
|
Prx1-Cre-p53fl/fl-Rbfl/fl |
18% [55]; 29% [56] |
|
| Pre-Osteoblasts |
Osx-Cre-Rbfl/fl |
0% [24]; 0% [25] |
|
Osx-Cre-p53fl/fl |
100% [24]; 100% [25] |
|
|
Osx-Cre-p53fl/fl-Rbfl/fl |
53% [24]; 100% [25] |
|
|
Osx-Cre-p53fl/fl-Rbfl/+ |
72% [24]; 100% [25] |
|
|
Col1〈13.6-Cre-p53fl/fl |
60% [193] |
|
| Osteoblasts |
Col1〈12.3-Cre-p53fl/fl |
85% [55] |
| Osteocalcin-SV40 T antigen | 100% [156] |