Table 1.
Characteristics of studies included in a meta-analysis of the IL-18 polymorphisms and rheumatoid arthritis and systemic lupus erythematosus
| Disease | Author(year) | Country | Population |
Sample size |
Polymorphisms evaluated | Genotyping |
HWE in controls |
|---|---|---|---|---|---|---|---|
| (cases/controls) | Pvalue | ||||||
| RA |
Sivalingam SP.2003 [23] |
Singapore |
Chinese |
309(74/235) |
rs1946518 |
PCR-SSP |
<0.001 |
| RA |
Sivalingam SP.2003 [23] |
Singapore |
Chinese |
309(74/235) |
rs187238 |
PCR-SSP |
0.442 |
| RA |
Sivalingam SP.2003 [23] |
Singapore |
Indian |
45(23/22) |
rs1946518 |
PCR-SSP |
0.079 |
| RA |
Sivalingam SP.2003 [23] |
Singapore |
Indian |
45(23/22) |
rs187238 |
PCR-SSP |
0.548 |
| RA |
Sivalingam SP.2003 [23] |
Singapore |
Malay |
25(9/16) |
rs1946518 |
PCR-SSP |
0.605 |
| RA |
Sivalingam SP.2003 [23] |
Singapore |
Malay |
25(9/16) |
rs187238 |
PCR-SSP |
0.904 |
| RA |
Huang XZ.2007 [11] |
China |
Chinese |
287(119/168) |
rs1946518 |
PCR-SSP |
0.783 |
| RA |
Huang XZ.2007 [11] |
China |
Chinese |
288(120/168) |
rs187238 |
PCR-SSP |
0.728 |
| RA |
Sugiura T.2011 [25] |
Japan |
Japanese |
2432(1462/970) |
rs1946518 |
TaqMan |
0.052 |
| RA |
Ying B.2011 [14] |
China |
Chinese |
360(164/196) |
rs1946518 |
PCR–RFLP |
0.543 |
| RA |
Shi P.2011 [26] |
China |
Chinese |
207(107/100) |
rs1946518 |
PCR-SSP |
0.115 |
| RA |
Shi P.2011 [26] |
China |
Chinese |
207(107/100) |
rs187238 |
PCR-SSP |
0.677 |
| SLE |
Xu Q.2007 [12] |
Singapore |
Chinese |
231(113/118) |
rs1946518 |
PCR–RFLP |
0.050 |
| SLE |
Xu Q.2007 [12] |
Singapore |
Chinese |
231(113/118) |
rs187238 |
PCR-SSP |
0.334 |
| SLE |
Lin YJ.2007 [13] |
China(Taiwan) |
Chinese |
301(160/141) |
rs1946518 |
Probe hybridization |
0.088 |
| SLE |
Lin YJ.2007 [13] |
China(Taiwan) |
Chinese |
307(161/146) |
rs187238 |
Probe hybridization |
0.290 |
| SLE |
Lan Y.2008 [27] |
China |
Chinese |
275(115/160) |
rs1946518 |
PCR–RFLP |
0.606 |
| SLE |
Lan Y.2008 [27] |
China |
Chinese |
275(115/160) |
rs187238 |
PCR–RFLP |
0.727 |
| SLE |
Chen DY.2009 [28] |
China(Taiwan) |
Chinese |
339(165/174) |
rs1946518 |
PCR–RFLP |
0.130 |
| SLE |
Hirankarn N.2009 [29] |
Thailand |
Thai |
258(116/142) |
rs1946518 |
PCR-SSP |
0.061 |
| SLE |
Hirankarn N.2009 [29] |
Thailand |
Thai |
258(116/142) |
rs187238 |
PCR-SSP |
0.868 |
| SLE |
Ye ZZ.2009 [24] |
China |
Chinese |
289(165/124) |
rs1946518 |
PCR-SSP |
0.549 |
| SLE | Ye ZZ.2009 [24] | China | Chinese | 289(165/124) | rs187238 | PCR-SSP | 0.030 |