Table 2.
Meta-analysis of the IL-18 gene polymorphisms and RA risk
| Genetic model | Comparisons |
Test of association |
Test of heterogeneity |
Publication bias |
||||
|---|---|---|---|---|---|---|---|---|
| OR | 95 % CI | Pvalue | Model | I2 | Pvalue | Pvalue | ||
| rs1946518 |
|
|
|
|
|
|
|
|
| Additive |
7 |
0.752 |
0.562-1.006 |
0.055 |
R |
77.80% |
<0.001 |
0.065 |
| Dominant |
7 |
0.730 |
0.479-1.113 |
0.144 |
R |
74.40% |
0.001 |
0.067 |
| Recessive |
7 |
0.537 |
0.271-1.064 |
0.075 |
R |
76.20% |
<0.001 |
0.290 |
| rs187238 |
|
|
|
|
|
|
|
|
| Additive |
5 |
1.316 |
0.828-2.092 |
0.246 |
R |
48.90% |
0.098 |
0.845 |
| Dominant |
4 |
1.196 |
0.466-3.073 |
0.710 |
F |
45.80% |
0.136 |
0.445 |
| Recessive | 5 | 1.347 | 0.963-1.885 | 0.082 | F | 22.40% | 0.272 | 0.657 |
R: random model F: fixed model.