Table 3.
Studies of the rs1946518 and rs187238 polymorphisms in IL-18 gene and risk of RA and SLE under additive model grouped by study characteristics
| Study characteristics |
Effect estimate of RA |
Effect estimate of SLE |
||||||
|---|---|---|---|---|---|---|---|---|
| Comparisons | I2 | OR (95% CI) | Pvaluea | Comparisons | I2 | OR (95% CI) | Pvaluea | |
|
rs1946518 |
7 |
77.80% |
0.752(0.562-1.006) |
0.055 |
6 |
88.10% |
0.684(0.455-1.028) |
0.068 |
| Population |
|
|
|
|
|
|
|
|
| Chinese |
4 |
52.90% |
0.688(0.532-0.889) |
0.004 |
5 |
87.00% |
0.606(0.396-0.930) |
0.022 |
| Other |
3 |
40.10% |
1.074(0.958-1.205) |
0.702 |
1 |
NA |
1.250(0.883-1.771) |
0.208 |
| Genotyping method |
|
|
|
|
|
|
|
|
| PCR-SSP |
5 |
36.50% |
0.636(0.519-0.781) |
<0.001 |
2 |
96.70% |
0.596(0.139-2.560) |
0.487 |
| PCR–RFLP |
1 |
NA |
0.817(0.604-1.105) |
0.189 |
3 |
74.60% |
0.670(0.454-0.989) |
0.044 |
| other |
1 |
NA |
1.088(0.969-1.222) |
0.155 |
1 |
NA |
0.945(0.686-1.303) |
0.731 |
| Sample size |
|
|
|
|
|
|
|
|
| ≥300 |
3 |
50.60% |
0.959(0.781-1.178) |
0.693 |
3 |
76.80% |
0.773(0.519-1.152) |
0.207 |
| <300 |
4 |
0.00% |
0.559(0.438-0.715) |
<0.001 |
3 |
93.50% |
0.605(0.267-1.369) |
0.228 |
| HWE status |
|
|
|
|
|
|
|
|
| Meeting HWE |
6 |
81.30% |
0.727(0.513-1.031) |
0.073 |
6 |
88.10% |
0.684(0.455-1.028) |
0.068 |
| Deviating HWE |
1 |
NA |
0.857(0.590-1.244) |
0.416 |
0 |
NA |
NA |
NA |
|
rs187238 |
5 |
48.90% |
1.296(0.959-1.751) |
0.246 |
5 |
33.70% |
1.166(0.948-1.435) |
0.145 |
| Population |
|
|
|
|
|
|
|
|
| Chinese |
3 |
70.30% |
1.262(0.703-2.264) |
0.436 |
4 |
45.60% |
1.209(0.961-1.520) |
0.105 |
| Other |
2 |
0.00% |
1.628(0.631-4.199) |
0.314 |
1 |
NA |
0.996(0.614-1.616) |
0.986 |
| Genotyping method |
|
|
|
|
|
|
|
|
| PCR-SSP |
5 |
48.90% |
1.296(0.959-1.751) |
0.246 |
3 |
0.00% |
1.300(0.991-1.705) |
0.416 |
| Other |
0 |
NA |
NA |
NA |
2 |
65.10% |
0.987(0.570-1.710) |
0.963 |
| Sample size |
|
|
|
|
|
|
|
|
| ≥150 |
3 |
70.30% |
1.262(0.703-2.264) |
0.436 |
2 |
0.00% |
1.351(0.990-1.845) |
0.058 |
| <150 |
2 |
0.00% |
1.628(0.631-4.199) |
0.314 |
3 |
54.70% |
1.040(0.686-1.577) |
0.854 |
| HWE status |
|
|
|
|
|
|
|
|
| Meeting HWE |
5 |
48.90% |
1.296(0.959-1.751) |
0.246 |
4 |
34.20% |
1.095(0.870-1.377) |
0.439 |
| Deviating HWE | 0 | NA | NA | NA | 1 | NA | 1.537(0.942-2.508) | 0.085 |
a: p value of Z test NA: not available.