Table 1.
Median and range of adiponectin, resistin, leptin, active PAI-1, MCP-1, IL-1α and TNF-α plasma concentrations of patients operated on for colorectal carcinoma (CRC) and morbid obesity (MO) as well as healthy blood donors (BD)
| Parameters Intra-CV% Inter-CV% | CRC (n=67) | MO (n=37) | BD (n=60) | CRC vs. BD | MO vs. BD | CRC vs. MO |
|---|---|---|---|---|---|---|
| Adiponectin (μg/ml) |
17.1 |
↓9.4 |
14.7 |
n.s. |
p<0.001 |
p<0.001 |
| 3.9 / 7.8 |
(4.3 – 51.0) |
(3.8 – 57.8) |
(5.7 – 54.0) |
|||
| Adiponectin females (μg/ml) |
21.9 |
↓12.4 |
22.5 |
n.s. |
p<0.001 |
p=0.002 |
| (7.0 – 40.5) |
(5.3 – 57.8) |
(9.8 – 54.0) |
||||
| Adiponectin males (μg/ml) |
14.2 |
↓8.3 |
11.8 |
n.s. |
p=0.001 |
p<0.001 |
| (4.3 – 51.0) |
(3.8 – 12.3) |
(5.7 – 30.7) |
||||
| Leptin (ng/ml) |
↓2.6 |
↑45.0 |
10.9 |
p<0.001 |
p<0.001 |
p<0.001 |
| 6.4 / 9.6 |
(0.3 – 33.3) |
(1.7 – 97.5) |
(0.3 – 58.5) |
|||
| Leptin females |
↓6.7 |
↑47.3 |
15.8 |
p=0.011 |
p<0.001 |
p<0.001 |
| (0.3 - 33.3) |
(16.1 – 97.5) |
(0.7 – 58.5) |
||||
| Leptin males |
↓1.7 |
↑34.2 |
4.7 |
p=0.001 |
p<0.001 |
p<0.001 |
| (0.3 – 19.6) |
(1.7 – 90.9) |
(0.3 – 19.1) |
||||
| Resistin (ng/ml) |
10.9 |
9.9 |
10.8 |
n.s. |
n.s. |
n.s. |
| 8.3 / 11.1 |
(4.2 – 43.5) |
( 3.7 – 83.6) |
(5.2 – 24.9) |
|||
| MCP-1 (pg/ml) |
↑127 |
↑108 |
43.9 |
p<0.001 |
p<0.001 |
p=0.047 |
| 5.1 / 11.2 |
(22.7 – 451) |
(39.6 – 293) |
(12.1 – 150) |
|||
| Active PAI-1 (ng/ml) |
↑13.2 |
↑57.5 |
6.0 |
p<0.001 |
p<0.001 |
p<0.001 |
| 17.4 / 20.0 |
(2.4 – 53.2) |
(3.7 – 176.7) |
( 2.4 – 31.3) |
|||
| TNF-α(pg/ml) |
4.8 (n=63) |
4.0 |
3.9 |
n.s. |
n.s. |
n.s. |
| 9.4 / 10.7 |
(2.4 – 74.7) |
(2.4 – 26.8) |
( 2.4 – 10.9) |
|||
| IL-1α (pg/ml) |
↑52.4 (n=63) |
↑59.4 |
11.0 |
p<0.001 | p<0.001 | n.s. |
| 20.0 / 35.7 | (9.2 – 1322) | (9.2 – 210.0) | ( 9.2 – 168) |
↓↑: Significantly elevated/lowered concentrations compared to BD.The inter- and intra-assay CVs are given below the corresponding parameters.