Table 1.
Patient characteristics
| 12.5 mg (N = 12) | 25 mg (N = 14) | 37.5 mg (N = 12) | ||
|---|---|---|---|---|
| Age (years) | Median (range) | 63.0 (45–81) | 58.0 (44–75) | 69.5 (48–81) |
| Sex | Female/male | 4/8 | 4/10 | 4/8 |
| Body mass index (kg/m2) | Mean ± SD | 22.6 ± 2.20 | 25.0 ± 4.15 | 24.7 ± 4.72 |
| Etiology of liver disease | HCV/HBV/cryptogenic | 7/4/1 | 9/3/2 | 10/1/2a |
| Child–Pugh classification | A/B | 8/4 | 8/6 | 7/5 |
| APRI | Mean ± SD | 4.3 ± 2.0 | 4.9 ± 2.8 | 4.9 ± 2.8 |
| FIB4 | Mean ± SD | 12.7 ± 3.6 | 13.8 ± 4.5 | 16.5 ± 8.2 |
| Baseline platelet count (/μL) | Median (range) | 42,500 (36,000–49,000) | 38,000 (19,000–48,000) | 40,000 (23,000–49,000) |
| Total bilirubin (mg/dL) | Mean ± SD | 1.51 ± 1.19 | 1.53 ± 0.62 | 1.27 ± 0.52 |
| Creatinine (mg/dL) | Mean ± SD | 0.70 ± 0.22 | 0.72 ± 0.16 | 0.83 ± 0.26 |
| Creatinine clearance (mL/min) | Mean ± SD | 93.5 ± 29.7 | 106.1 ± 34.9 | 84.2 ± 40.4 |
HBV hepatitis B virus, HCV hepatitis C virus, SD standard deviation, APRI aspartate aminotransferase-to-platelet ratio index
aOne patient in the 37.5 mg group was infected with both HCV and HBV