Table 1.
Pharmacokinetic parameters estimated by noncompartmental analysis of the plasma concentration-time profiles of amiodarone (AM) and mono-N-desethylamiodarone (MDEA, major metabolite of AM) obtained in rats after the simultaneous coadministration in single dose of Paullinia cupana extract (821 mg/kg, p.o.), or vehicle (0.5% carboxymethylcellulose aqueous solution), with AM (50 mg/kg, p.o.) by oral gavage (n = 6, unless otherwise noted).
| Parameter | AMPaullinia | AMVehicle | ||
|---|---|---|---|---|
| AM | MDEA | AM | MDEA | |
| t max (h) | 3.67 ± 1.17 | NA | 1.83 ± 0.48 | 7.20 ± 1.36a |
| C max (μg/mL) | 0.370 ± 0.043* | NA | 1.378 ± 0.179 | 0.125 ± 0.012a |
| AUC0–t (μg·h/mL) | 5.387 ± 0.619* | ND | 12.774 ± 0.688 | ND |
| AUC0–∞ (μg·h/mL) | 12.050 ± 2.118# | ND | 21.431 ± 2.077 | ND |
| k el (h−1) | 0.0310 ± 0.0044 | ND | 0.0433 ± 0.0082 | ND |
| t 1/2el (h) | 24.18 ± 2.75 | ND | 20.73 ± 5.74 | ND |
| MRT (h) | 36.87 ± 4.28 | ND | 28.64 ± 7.74 | ND |
NA: not available.
ND: not determined.
a n = 5.
*P < 0.001, significantly different from the control group.
# P < 0.05, significantly different from the control group.