Table 2.
Naturally occurring compounds targeting TBK1.
| Compound | Cells | Action target of TBK1 | Reference |
|---|---|---|---|
| Resveratrol |
Epithelial cells RAW264.7 cells |
Production of IL-6, TNF-α, IFN-1, and iNOS | [13, 37] |
| Luteolin | RAW264.7 macrophage | Expression of TNF-α, IL-6, IL-12, IP-10, IFN-β, CXCL9, and IL-27 | [38] |
| Quercetin | RAW264.7 macrophage | Expression of IP-10, IFN-β | [38] |
| EGCG | RAW264.7 macrophage | TRIF-dependent signaling pathways | [38, 39] |
| Chrysin | RAW264.7 macrophage | Expression of IP-10, IFN-β | [38] |
| Eriodictyol | RAW264.7 macrophage | Expression of IP-10, IFN-β | [38] |