TABLE 1.

Targeted VEGF and VEGF Receptor Imaging Studies in the Literature

Study Group, Year	Imaging Technique	Tumor Model	Contrast Agent and Label Used	Reference
Lyshcik et al., 2007	Ultrasound	Breast cancer in mice	VEGF receptor-2–targeted ultrasound contrast agent	52
Lee et al., 2008	Ultrasound	Breast cancer in mice	VEGF receptor-2–targeted ultrasound contrast agent	53
Willmann et al., 2008	Ultrasound	Angiosarcoma in mice	VEGF receptor-2–targeted ultrasound contrast agent	54
Hsu et al., 2007	PET	Glioblastoma in mice	64Cu-DOTA-VEGF121	55
Cai et al., 2006	PET	Glioblastoma in mice	64Cu-labeled VEGF121	56
Nagengast et al., 2007	SPECT and PET	SKOV-3 ovarian tumor xenograft in mice	111In (SPECT), 89Zr (PET)	57
Wang et al., 2007	PET	Murine breast cancer in mice	64Cu-DOTA-VEGF (DEE)	58
Backer et al., 2005	Near-infrared fluorescence imaging	Breast cancer in mice	5th-generation dendrimer tagged with near-infrared Cy5	59

Note—VEGF = vascular endothelial growth factor, DOTA = tetraazacyclododecanetetraacetic acid.