TABLE 3.

Targeted Matrix Metalloproteinase (MMP) Imaging Studies in the Literature

Study Group, Year	Imaging Technique	Tumor Model	Contrast Agent and Label Used	Reference
Furumoto et al., 2003	PET	Breast cancer in mice	18F-labeled MMP	76
Medina et al., 2005	SPECT	Xenograft tumor in mice	125I- and 99mTc-labeled gelatinase inhibitory peptide	77
Zheng et al., 2004	PET	Breast cancer in mice	11C-labeled MMP inhibitors	78
Bremer et al., 2001	Near-infrared fluorescence imaging	Human fibrosarcoma in mice	Optical fluorophores	79