. Author manuscript; available in PMC: 2012 Dec 16.

Published in final edited form as: Bioorg Med Chem. 2011 May 27;19(22):6654–6657. doi: 10.1016/j.bmc.2011.05.041

Table 1.

In vitro activities of 1 and AMB against melanized C. neoformans var. grubii and var. gattii grown in the presence of catecholamines by the halo assay.

Sample^a	Substrate^b	Halo diameter, mm C. neoformans
Sample^a	Substrate^b	var. grubii	var. gattii
1	L-dopa	17^c	17^c
	Dopamine	15^c	18^c
	Epinephrine	12^c	12^c

AMB	L-dopa	21	17
	Dopamine	18	22
	Epinephrine	18	18

Concentration per disk was at 20 μg.

Cells were grown in the presence of 1mM catecholamine in the minimal medium for 6 to 8 days to promote melanization.

Halo surrounding the disk revealed the presence of non-melanized cells.