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In vitro activity of ptilomycalin A (1) and AMB, alone and in combination against C. neoformans by halo assay.
| Sample | Dose. per disk (μg) | Halo diameter mm C. neoformansa | |
|---|---|---|---|
| var. gattii. | var. grubii | ||
| AMB | 2 | 10.0 | 15.5 |
| 1 | 10 | 9.50 b | 13.5b |
| AMB + 1 | 2 +10 | 15.0 | 21.0 |
Cells were grown in the presence of 1mM L-dopa for 6 days.
Halo surrounding the disk revealed the presence of non-melanized cells.
