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. Author manuscript; available in PMC: 2012 Dec 16.
Published in final edited form as: Nature. 2012 Mar 21;485(7398):321–326. doi: 10.1038/nature10954

Figure 1. Overall view of μOR receptor structure.

Figure 1

a, Views from within the membrane plane (left), extracellular side (top, center panel) and intracellular side (bottom, center panel) show the typical seven-pass transmembrane GPCR architecture of the μOR. The ligand, β-FNA, is shown in green spheres. b, The chemical structure of morphine. c, The chemical structure of β-FNA and the chemical reaction with the side chain of K2335.39 in the receptor are shown. β-FNA is a semisynthetic opioid antagonist derived from morphine, shown at right.