Table 1.
Subject characteristics
| LOW B12 (N = 28) |
NORMAL B12 (N = 28) |
|||||
|---|---|---|---|---|---|---|
| VARIABLE | MEAN | SD | MEAN | SD | ||
| Demographics | ||||||
| Age | 86.8 | ± | 6.9 | 87.0 | ± | 5.8 |
| Gender | 25F, 3M | 25F, 3M | ||||
| Education (years) | 10.7 | ± | 3.1 | 10.7 | ± | 2.8 |
| Dementia Characteristics | ||||||
| Duration (years) | 4.8 | ± | 3.3 | 5.5 | ± | 4.2 |
| Hachinski Score | 3.9 | ± | 3.0 | 3.9 | ± | 2.9 |
| Neuropsychological | ||||||
| MMSE | 11.9 | ± | 8.9 | 11.6 | ± | 8.0 |
| DRS | 64.4 | ± | 39.6 | 63.8 | ± | 45.4 |
| GDS | 5.2 | ± | 3.3 | 4.5 | ± | 3.5 |
| BPRS | 27.7 | ± | 7.6 | 24.4 | ± | 5.9 |
| Hematological | ||||||
| Serum B12 (pg/mL) | 186 | ± | 43* | 521 | ± | 226 |
| RBC Folate (ng/mL) | 364 | ± | 157† | 524 | ± | 161 |
| Serum LDH (U/L) | 148 | ± | 38 | 165 | ± | 39 |
| WBC (×1000/mm3) | 6.8 | ± | 1.8 | 7.4 | ± | 2.1 |
| RBC (×1000/mm3) | 4.0 | ± | 0.4 | 4.3 | ± | 1.2 |
| Hemoglobin (g/dL) | 12.1 | ± | 1.4 | 12.4 | ± | 1.5 |
| Hematocrit (%) | 36.3 | ± | 4.4 | 37.2 | ± | 4.7 |
| MCV (fL) | 91.9 | ± | 5.5 | 91.9 | ± | 6.3 |
| Platelets (×1000/mm3) | 255 | ± | 56 | 258 | 90 | |
Note: MMSE, Mini-Mental State Examination; DRS, Dementia Rating Scale; GDS, Geriatric Depression Scale; BPRS, Brief Psychiatric Rating Scale; LDH, lactate dehydrogenase; MCV; erythrocyte mean corpuscular volume.
*
Differs from Normal B12 group, P<0.001, t-test;
†
Differs from Normal B12 group, p=0.001, t-test. RBC folate levels were available for 24 subjects in each group.