Table 2.
Effect of B12 Replacement on Laboratory Variables in Low B12 Dementia Subjects
| BASELINE |
8 WEEKS |
||||||
|---|---|---|---|---|---|---|---|
| MEAN | SD | MEAN | SD | P | |||
| Methylmalonic Acid (nmol/L) | 592 | ± | 626 | 179 | ± | 66 | <0.001 |
| Homocysteine (μmol/L) | 17.8 | ± | 8.2 | 12.3 | ± | 5.6 | <0.001 |
| Serum LDH(U/L) | 148 | ± | 38 | 145 | ± | 46 | 0.514 |
| WBC (×1000/mm3) | 6.82 | ± | 1.79 | 6.98 | ± | 1.75 | 0.625 |
| RBC (×1000/mm3) | 3.95 | ± | 0.45 | 4.09 | ± | 0.51 | 0.032 |
| Hemoglobin (g/dL) | 12.1 | ± | 1.4 | 12.5 | ± | 1.7 | 0.043 |
| Hematocrit (%) | 36.3 | ± | 4.4 | 37.1 | ± | 5.0 | 0.148 |
| MCV (fL) | 91.9 | ± | 5.5 | 90.6 | ± | 4.7 | 0.035 |
| Platelets(×1000/mm3) | 255 | ± | 56 | 261 | ± | 58 | 0.569 |
Note: LDH, lactate dehydrogenase; WBC, white blood cell count; RBC, red blood cell count; MCV, erythrocyte mean corpuscular volume.
P-values are from paired t-tests for all variables except Methylmalonic Acid, which is from Wilcoxon matched-pairs test.