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. 2012 Aug 29;23(12):1247–1257. doi: 10.1089/hum.2012.042

FIG. 4.

FIG. 4.

Distribution of ICLV and IDLV insertion sites in human vascular smooth muscle cells. (A) Frequency of ICLV and IDLV integration inside RefSeq genes. (B) Distribution of insertion sites inside and 10 kb upstream of RefSeq genes normalized to the expected random distribution of 5.000 computer-simulated random insertion sites. (C) ICLV insertion sites in VSMCs show regional clustering in common insertion sites (CIS) in three independently analyzed patient samples to a similar frequency. (D) Vector copy number (VCN) normalized to erythropoietin (EPO) gene at 14 days post-transduction. ICLV, integrase-competent lentiviral vectors.