FIG. 1.

Serum proinsulin and glucose measured 10, 40, 70, and 100 days after vector administration. (A) Serum levels of human proinsulin (hPi) measured at P30, P60, P90, and P120 in P23H rats injected with adeno-associated viral vector serotype 1 (AAV1)-hPi at P20. Note that significant expression of hPi from the viral vectors was found as early as 10 days after injection. No hPi was detected in serum from control rats (not shown). (B) Glycemia in hPi+ and hPi− rats measured at P20, P30, P60, P90, and P120. Error bars indicate SEM.