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. Author manuscript; available in PMC: 2012 Dec 17.
Published in final edited form as: Curr Pharm Biotechnol. 2007 Dec;8(6):332–336. doi: 10.2174/138920107783018444

Figure 1. human p63.

Figure 1

a) Schema of the human p63 gene structure: Alternative splicing (α, β, γ) and alternative promoters (P1 and P2) are indicated.

b) p63 protein isoforms: TAp63 proteins encoded from promoter P1 contain the conserved N-terminal domain (FxxψW) of transactivation (TA). ΔNp63 proteins encoded from promoter P2 are amino-truncated proteins containing an N-terminal transactivating domain different from TAp63 proteins. Numbers indicate the exons encoding p63 protein isoforms. Black boxes indicate conserved domains.