a) Schema of the human p63 gene structure: Alternative splicing (α, β, γ) and alternative promoters (P1 and P2) are indicated.
b) p63 protein isoforms: TAp63 proteins encoded from promoter P1 contain the conserved N-terminal domain (FxxψW) of transactivation (TA). ΔNp63 proteins encoded from promoter P2 are amino-truncated proteins containing an N-terminal transactivating domain different from TAp63 proteins. Numbers indicate the exons encoding p63 protein isoforms. Black boxes indicate conserved domains.