Figure 4.

Serial mean (±SEM) arterial base excess (ABE), bicarbonate (HCO₃), lactate, blood urea nitrogen (BUN), creatinine, aspartate and alanine transaminases (AST and ALT, respectively), creatine phosphokinase (CK), alveolar to arterial oxygen gradient (AaO₂), and circulating neutrophils, lymphocytes, and platelets at 4, 8, and 24 hrs in animals challenged with diluent alone (crosshatched bars) or with 24-hr edema toxin (ET) infusions and treated at the start of ET with placebo (open bars) or a chimpanzee-derived monoclonal antibody against protective antigen (W1-mAb), 1× (gray bars) or 10× (black bars). The p^α and p^β values demonstrate the level of significance for the effect of W1-mAb across the time points compared to placebo in ET animals and for the interaction between these effects and time, respectively. PA, protective antigen.