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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Adv Anat Pathol. 2013 Jan;20(1):45–52. doi: 10.1097/PAP.0b013e31827bc24d

Fig 3. Molecular genetic alterations and pathway aberrations in ERON.

Fig 3

The common molecular genetic changes shared by clear cell and endometrioid carcinomas include ARID1A mutation, PIK3CA/PTEN mutation, and PP2R1A mutation. Mutations in CTNNB1 and mismatch repair genes such as MHL1 and MSH2 leading to microsatellite instability are almost always detected in endometrioid carcinoma but not in clear cell carcinoma. Genes in red indicate inactivating (loss of function) mutations, and genes in blue represent activating (gain of function) mutations. The larger the font, the greater the observed frequency of mutation of the gene. Asterisks indicate molecular changes that are predominantly found in ovarian endometrioid carcinoma.