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. Author manuscript; available in PMC: 2012 Dec 17.
Published in final edited form as: Alcohol Clin Exp Res. 2009 Jul 23;33(10):1794–1805. doi: 10.1111/j.1530-0277.2009.01018.x

Figure 7. Ethanol sensitivity and rapid ethanol tolerance in scab α integrin mutants.

Figure 7

eRING assays were performed with vapor from a 50% ethanol solution. (A and B) T50 was decreased in scb mutants (A, *t test, p<0.0001; B, one-way ANOVA, p<0.001). (B) scbvol1 and scbvol2 heterozygotes had lower T50 values than w[CS] (*Bonferroni’s multiple comparison test, p<0.05) while flies transheterozygous for these two alleles exhibited a further reduction in T50 (**Bonferroni’s multiple comparison test, p< 0.05). (C and D) The development of rapid ethanol tolerance is altered by mutations in scb (C, *t test, p<0.0001; D, one-way ANOVA, p<0.0001). (D) Rapid ethanol tolerance is elevated in scbVol1 and scbVol2 heterozygotes (**Bonferroni’s multiple comparison test, p<0.05), but less so in scbvol1/scbvol2 transheterozygotes (*Bonferroni’s multiple comparison test, p<0.05). Data in (A) and (B) were compiled from three independent experiments for a total of 10–30 vials of 25 flies per group. All data are mean ± S.E.M.