Figure 5.

Hypothetical mechanism for induction of non-neutralizing antibodies by flexible CD4BD^core mimetics. A flexible mimetic can detect innate antibodies (or B cell receptors) that utilize the FRs for CD4BD^core recognition and induce the synthesis of such antibodies if mechanisms for productive B cell stimulation can be devised (Bottom). When used as an immunogen, the conformation of the flexible mimetic can adapt to the structure of the B cell receptor CDRs by the induced-fit mechanism, which will corrupt the adaptive antibody response and skewed the response toward production of non-neutralizing antibodies directed to the incorrect CD4BD^core conformation (Top).