Table 2.
Midazolam | Pre-ginseng | Post-ginseng | Post-ginseng/Pre-ginseng | ||
---|---|---|---|---|---|
| |||||
Geometric Mean | % CV | Geometric Mean | % CV | Geometric Mean Ratios | |
AUC0-∞ (ng · hr/mL) | 120 | 69 | 79 | 51 | 0.66 (0.55–0.78) |
Cmax (ng/mL) | 39 | 67 | 29 | 41 | 0.74 (0.56 – 0.93) |
Tmax (hr)a | 0.5 | 0.5–1.0b | 0.5 | 0.5–1.5b | – |
T ½(hr) | 5.6 | 32 | 4.0 | 84 | 0.71 (0.53–0.90) |
Cl/F (mL/hr) | 67 | 43 | 101 | 58 | 1.51 (1.17–1.86) |
| |||||
Fexofenadine
| |||||
AUC0-∞ (ng · hr/mL) | 2036 | 39 | 1860 | 59 | 0.91 (0.69–1.14) |
Cmax (ng/mL) | 305 | 33 | 258 | 40 | 0.84 (0.67–1.02) |
Tmax (hr)a | 2.3 | 1.5–4.0b | 2.8 | 1.0–5.0b | – |
T ½ (hr) | 5.2 | 19 | 4.8 | 15 | 0.93 (0.85–1.01) |
Cl/F (mL/hr) | 59 | 41 | 65 | 36 | 1.09 (0.84–1.35) |
Median.
Ranges.