Table 2.

Midazolam and fexofenadine pharmacokinetic parameter values before and after 28 days of Panax ginseng administration in 12 healthy volunteers

Midazolam	Pre-ginseng		Post-ginseng		Post-ginseng/Pre-ginseng
	Geometric Mean	% CV	Geometric Mean	% CV	Geometric Mean Ratios
AUC0-∞ (ng · hr/mL)	120	69	79	51	0.66 (0.55–0.78)
Cmax (ng/mL)	39	67	29	41	0.74 (0.56 – 0.93)
Tmax (hr)a	0.5	0.5–1.0b	0.5	0.5–1.5b	–
T ½(hr)	5.6	32	4.0	84	0.71 (0.53–0.90)
Cl/F (mL/hr)	67	43	101	58	1.51 (1.17–1.86)
Fexofenadine
AUC0-∞ (ng · hr/mL)	2036	39	1860	59	0.91 (0.69–1.14)
Cmax (ng/mL)	305	33	258	40	0.84 (0.67–1.02)
Tmax (hr)a	2.3	1.5–4.0b	2.8	1.0–5.0b	–
T ½ (hr)	5.2	19	4.8	15	0.93 (0.85–1.01)
Cl/F (mL/hr)	59	41	65	36	1.09 (0.84–1.35)

^aMedian.

^bRanges.