Table 1.

Inhibitory potencies using an in vitro IN assay.^a

No.	R	IC50 Values (μM)
		3′-Processing	Strand transfer
2b	H	13.2 ± 3.1	0.16 ± 0.08
4b	Me	>111	11.5 ± 1.6
4c	nBu	>111	6.8 ± 0.9
4d	iPr	>111	5.4 ± 0.6
4e	Ph	>111	0.87 ± 0.08
4g	OH	36.0 ± 6.0	1.5 ± 0.3
4h		>111	0.4 ± 0.04

^aAssays were performed using a gel-based protocol with Mg²⁺ cofactor as describe in reference 12;

^bReported previously in references 12–14.