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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Oct 27;22(24):7309–7313. doi: 10.1016/j.bmcl.2012.10.088

Table 2.

Inhibitory potencies using an in vitro IN assay.a

graphic file with name nihms422332u2.jpg
No. X IC50 Values (μM)
3′-Processing Strand transfer
5a-1 NHMe 17.5 ± 3.0 0.12 ± 0.04
5a-2 NEt2 9.5 ± 1.2 0.054 ± 0.009
5a-3 graphic file with name nihms422332t2.jpg 14.7 ± 1.7 0.11 ± 0.01
5a-4 graphic file with name nihms422332t3.jpg 15.9 ± 1.3 0.24 ± 0.02
5a-5 graphic file with name nihms422332t4.jpg 30.2 ± 2.3 0.32 ± 0.05
5a-6 graphic file with name nihms422332t5.jpg 19.3 ± 0.6 0.31 ± 0.03
5a-7 graphic file with name nihms422332t6.jpg 23 ± 3 0.37 ± 0.04
5a-8 graphic file with name nihms422332t7.jpg 23 ± 4 0.4 ± 0.08
5a-9 graphic file with name nihms422332t8.jpg 21.2 ± 1.9 0.19 ± 0.08
5a-10 graphic file with name nihms422332t9.jpg 6.8 ± 1.1 0.047 ± 0.007
5a-11 graphic file with name nihms422332t10.jpg 11.7 ± 0.7 0.08 ± 0.01
5a-12 graphic file with name nihms422332t11.jpg 6.9 ± 0.6 0.058 ± 0.01
a

Assays were performed using a gel-based protocol with Mg2+ cofactor as described in reference 12.