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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Oct 27;22(24):7309–7313. doi: 10.1016/j.bmcl.2012.10.088

Table 3.

Inhibitory potencies using an in vitro IN assay.a

graphic file with name nihms422332u3.jpg
No. R X IC50 Values (μM)
3′-Processing Strand transfer
5b-2 Me NMe2 49.7 ± 4.0 2.8 ± 0.6
5c-2 nBu NMe2 >111 2.3 ± 0.4
5d-2 iPr NMe2 >111 0.19 ± 0.03
5d-10 iPr graphic file with name nihms422332t12.jpg >111 0.41 ± 0.06
5g-2 OH NMe2 7.6 ± 0.8 0.26 ± 0.08
5h-2 graphic file with name nihms422332t13.jpg NMe2 35.2 ± 2.6 0.25 ± 0.06
a

Assays were performed using a gel-based protocol with Mg2+ cofactor as describe in reference 12.