TABLE 2.
Amino Acid Properties
| Amino acid residues | Chemical property | Charge | Volume (A3) | Mass (daltons) | HP Scale | Surface Area | 2D structure propensity
|
||
|---|---|---|---|---|---|---|---|---|---|
| alpha helix | B-strand | Turn | |||||||
| Alanine (A) | aliphatic | 0 | 67 | 71.09 | 1.8 | 0.74 | 1.41 | 0.72 | 0.82 |
| Arginine I | basic | +1 | 148 | 156.19 | −4.5 | 0.64 | 1.21 | 0.84 | 0.90 |
| Asparagine (N) | amide | 0 | 96 | 114.11 | −3.5 | 0.63 | 0.76 | 0.48 | 1.34 |
| Aspartic Acid (D) | acidic | −1 | 91 | 115.09 | −3.5 | 0.62 | 0.99 | 0.39 | 1.24 |
| Cysteine(C) | reactive | 0 | 86 | 103.15 | 2.5 | 0.91 | 0.66 | 1.40 | 0.54 |
| Glutamine (Q) | amide | 0 | 114 | 128.14 | −3.5 | 0.62 | 1.27 | 0.98 | 0.84 |
| Glutamic Acid (E) | acidic | −1 | 109 | 129.12 | −3.5 | 0.62 | 1.59 | 0.52 | 1.01 |
| Glycine (G) | small | 0 | 48 | 57.05 | −0.4 | 0.72 | 0.43 | 0.58 | 1.77 |
| Histidine (H) | aromatic | 0 | 118 | 137.14 | −3.2 | 0.78 | 1.05 | 0.80 | 0.81 |
| Isoleucine (I) | aliphatic | 0 | 124 | 113.16 | 4.5 | 0.88 | 1.09 | 1.67 | 0.47 |
| Leucine (L) | aliphatic | 0 | 124 | 113.16 | 3.8 | 0.85 | 1.34 | 1.22 | 0.57 |
| Lysine (K) | basic | +1 | 135 | 128.17 | −3.9 | 0.52 | 1.23 | 0.69 | 1.07 |
| Methionine (M) | aliphatic | 0 | 124 | 131.19 | 1.9 | 0.85 | 1.30 | 1.14 | 0.52 |
| Phenylalanine (F) | aromatic | 0 | 135 | 147.18 | 2.8 | 0.88 | 1.16 | 1.33 | 0.59 |
| Proline (P) | cyclic imino | 0 | 90 | 97.12 | −1.6 | 0.64 | 0.34 | 0.31 | 1.32 |
| Serine (S) | hydroxyl | 0 | 73 | 87.08 | −0.8 | 0.66 | 0.57 | 0.96 | 1.22 |
| Threonine (T) | hydroxyl | 0 | 93 | 101.11 | −0.7 | 0.70 | 0.76 | 1.17 | 0.90 |
| Tryptophane (W) | aromatic | 0 | 163 | 186.21 | −0.9 | 0.85 | 1.02 | 1.35 | 0.65 |
| Tyrosine (Y) | aromatic | 0 | 141 | 163.18 | −1.3 | 0.76 | 0.74 | 1.45 | 0.76 |
| Valine (V) | aliphatic | 0 | 105 | 99.14 | 4.2 | 0.86 | 0.90 | 1.87 | 0.41 |
Volume = volume enclosed by van der Waals radii. Mass = molecular weight of nonionized amino acid minus that of water, both adopted from [28]. HP scale = degree of hydrophobicity of amino acid side chains, based on [29]. Surface area = mean fraction buried, based on [30]. Secondary structure propensity = normalized frequencies for each conformation, adopted from [28], is the fraction of residues of each amino acid that occurred in that conformation, divided by this fraction for all residues.