. Author manuscript; available in PMC: 2012 Dec 17.

Published in final edited form as: IEEE/ACM Trans Comput Biol Bioinform. 2008 Apr-Jun;5(2):291–300. doi: 10.1109/TCBB.2007.1074

TABLE 3.

Amino Acid Membership Classes

Name	Size	Feature	Membership classes	Numeric Class Conversion
Exchange Group	6	Conservative substitution	{HRK} {DENQ} {C} {STPAG} {MILV} {FYW}	1,2,3,4,5,6
Charge Polarity	4	Charge and Polarity	{HRK} {DE} {CTSGNQY} {APMLIVFW}	1,2,3,4
Hydrophobicity	3	Hydrophobicity	{DENQRK} {CSTPGHY} {AMILVFW}	1,2,3
Mass	3	Mass	{GASPVTC} {NDQEHILKM} {RFWY}	1,2,3
Structural	3	Surface Exposure	{DENQHRK} {CSTPAGWY} {MILVF}	1,2,3
2D Propensity	3	2D Propensity	{AEQHKMLR} {CTIVFYW} {SGPDN}	1,2,3