Table 1.
Demographic data of all cohorts
| Pedigrees | Subjects | Affected subjects |
Unaffected subjects |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Total | Male |
Female |
Male |
Female |
|||||||
| Human disease | Ethnicity | Data set name | n | n | n | Age (yrs) | n | Age (yrs) | n | Age (yrs) | n | Age (yrs) |
| Alcohol dependence | EA (CC) | SAGE+COGA | 2927 | 2927 | 883 | 39.0 ± 10.4 | 526 | 36.7 ± 8.8 | 445 | 37.9 ± 10.1 | 1073 | 39.0 ± 9.1 |
| Alcohol dependence | AA (CC) | SAGE+COGA | 1189 | 1189 | 428 | 41.0 ± 8.3 | 253 | 39.8 ± 6.8 | 169 | 40.2 ± 8.4 | 339 | 39.6 ± 6.8 |
| Alcohol dependence | EAu (Fam) | OZ-ALC | 1856 | 6410 | 1011 | 42.0 ± 8.4 | 622 | 39.2 ± 7.3 | 1709 | 46.3 ± 9.8 | 2213 | 45.6 ± 9.5 |
| Major depression | CA (CC) | PRSC | 3625 | 3625 | 548 | 44.2 ± 12.0 | 1257 | 41.2 ± 12.8 | 694 | 47.1 ± 14.4 | 1126 | 43.8 ± 13.7 |
| Bipolar disorder | EA (CC) | BDO+GRU | 1402 | 1402 | 190 | 43.1 ± 8.0 | 178 | 45.4 ± 10.0 | 532 | 54.7 ± 17.3 | 502 | 50.1 ± 17.6 |
| Bipolar disorder | EA (CC) | BARD+GRU | 1687 | 1687 | 322 | 42.1 ± 8.3 | 331 | 44.4 ± 9.7 | 532 | 54.7 ± 17.3 | 502 | 50.1 ± 17.6 |
| Bipolar disorder | AA (CC) | BARD+GRU | 812 | 812 | 39 | 42.4 ± 7.9 | 102 | 42.0 ± 7.8 | 272 | 46.0 ± 14.0 | 399 | 45.7 ± 13.5 |
| Schizophrenia | AA (CC) | GAIN | 2149 | 2149 | 746 | 41.9 ± 10.8 | 449 | 43.0 ± 9.8 | 362 | 46.2 ± 13.7 | 592 | 45.0 ± 12.9 |
| Schizophrenia | EA (CC) | GAIN | 2729 | 2729 | 947 | 42.5 ± 11.3 | 404 | 45.1 ± 11.2 | 634 | 53.5 ± 17.0 | 744 | 49.2 ± 16.7 |
| Schizophrenia | EA (CC) | nonGAIN | 2784 | 2784 | 996 | 42.3 ± 11.8 | 441 | 44.2 ± 12.4 | 669 | 51.8 ± 15.3 | 678 | 47.9 ± 16.1 |
| Schizophrenia | AA (CC) | nonGAIN | 118 | 118 | 60 | 41.5 ± 11.3 | 38 | 42.9 ± 10.5 | 20 | 49.7 ± 9.2 | 0 | — |
| Autism | EA (Fam) | AGP | 1366 | 4075 | 1121 | 7.2 ± 3.2 | 209 | 7.1 ± 3.0 | 0 | — | 0 | — |
| ADHD | CA (Fam) | IMAGE | 922 | 2757 | 802 | 10.9 ± 2.8 | 122 | 10.8 ± 3.0 | 0 | — | 0 | — |
| Alzheimer's disease | CA (Fam) | LOAD × 4 | 2243 | 5219 | 788 | 84.1 ± 8.1 | 1510 | 86.3 ± 8.7 | 486 | 66.7 ± 10.7 | 773 | 66.1 ± 10.5 |
| Alzheimer's disease | EA (CC) | GenADA | 1588 | 1588 | 340 | 77.6 ± 8.3 | 466 | 78.3 ± 8.8 | 279 | 74.4 ± 7.7 | 503 | 72.8 ± 8.1 |
| ALS | CA (CC) | GRU | 507 | 507 | 138 | 56.5 ± 11.9 | 123 | 59.2 ± 11.6 | 136 | 69.6 ± 8.6 | 110 | 69.8 ± 8.9 |
| Early onset stroke | EA (CC) | GEOS × 3 | 802 | 802 | 198 | 42.7 ± 6.1 | 174 | 38.7 ± 7.6 | 208 | 40.6 ± 6.4 | 222 | 37.8 ± 7.3 |
| Early onset stroke | AA (CC) | GEOS × 3 | 599 | 599 | 144 | 42.3 ± 6.2 | 165 | 41.0 ± 7.3 | 129 | 40.9 ± 6.5 | 161 | 38.4 ± 7.5 |
| Ischemic stroke | CA (CC) | ISGS | 485 | 485 | 119 | 71.8 ± 8.3 | 100 | 71.6 ± 8.1 | 128 | 69.7 ± 8.6 | 138 | 69.7 ± 8.9 |
| Parkinson's disease | CA (CC) | NGRC | 3986 | 3986 | 1346 | 67.2 ± 10.5 | 654 | 67.3 ± 11.0 | 769 | 70.7 ± 13.9 | 1217 | 70.1 ± 14.2 |
| Parkinson's disease | CA (CC) | PDRD+GRU | 1767 | 1767 | 537 | 70.5 ± 9.3 | 363 | 70.2 ± 10.0 | 346 | 53.5 ± 15.7 | 521 | 55.2 ± 11.2 |
| Parkinson's disease | CA (CC) | lng_coriell_pd | 1741 | 1741 | 560 | 66.3 ± 10.9 | 380 | 65.9 ± 11.2 | 336 | 62.3 ± 14.4 | 465 | 56.0 ± 17.2 |
In the family data, only the affected and unaffected offspring are listed. Data set names refer to dbGaP.
n, sample size; yrs, years; CC, case–control sample; Fam, family sample. EA, European-American; AA, African-American; EAu, European-Australian; CA, Caucasian; ADHD, attention deficit hyperactivity disorder; ALS, amyotrophic lateral sclerosis. [GenADA: Li et al. Arch Neurol. 2008; 65(1):45–53; Filippini et al. Neuroimage. 2009;44(3):724–728. AGP: The AGP Consortium. Nature. 2010;466(7204):368–372; Human Molecular Genetics. 2010;19(20):4072–4082; Nature Genetics. 2007;39(3):319–328].