Table 3.

P-values for associations between rare variant constellations and diseases

Diseases	Ethnicity	Data set name	Tests	MAF upper bound	ADH cluster	ADH1A	ADH1B	ADH1C	ADH4	ADH5	ADH6	ADH7
Alcohol dependence	EA	SAGE+COGA	Fp	0.01	0.045	0.231	0.979	0.591	0.085	0.725	0.008	0.076
Alcohol dependence	EA	SAGE+COGA	Fp	0.05	0.707	0.929	0.965	0.210	0.893	0.965	0.655	0.650
Alcohol dependence	EA	SAGE+COGA	VT	Variable	0.089	0.239	0.887	0.877	0.329	0.986	0.010	0.138
Alcohol dependence	EA	SAGE+COGA	Collapsing	0.05	0.542	0.827	0.943	0.197	0.693	0.847	0.479	0.568
Alcohol dependence	EAu	OZ-ALC	Fp	0.01	0.206	0.092	0.509	0.056	0.645	0.765	0.397	0.195
Alcohol dependence	EAu	OZ-ALC	Fp	0.05	0.027	0.635	0.025	0.034	0.315	0.480	0.449	0.009
Alcohol dependence	EAu	OZ-ALC	VT	Variable	0.055	0.396	0.103	0.023	0.344	0.797	0.030	0.047
Alcohol dependence	EAu	OZ-ALC	Collapsing	0.05	0.038	0.851	0.016	0.038	0.335	0.482	0.472	0.005
Alcohol dependence	AA	SAGE+COGA	Fp	0.01	0.543	0.941	0.795	0.452	0.492	0.447	0.496	0.889
Alcohol dependence	AA	SAGE+COGA	Fp	0.05	0.050	0.784	0.723	0.151	0.077	0.121	0.051	0.491
Alcohol dependence	AA	SAGE+COGA	VT	Variable	0.226	0.822	0.854	0.563	0.273	0.173	0.099	0.981
Alcohol dependence	AA	SAGE+COGA	Collapsing	0.05	0.038	0.555	0.861	0.139	0.051	0.069	0.056	0.581
Major depression	CA	PRSC	Fp	0.01	0.307	0.643	0.282	0.339	0.765	0.646	0.040	0.697
Major depression	CA	PRSC	Fp	0.05	0.107	0.349	0.319	0.856	0.123	0.071	0.294	0.675
Major depression	CA	PRSC	VT	Variable	0.557	0.198	0.678	0.496	0.607	0.314	0.302	0.133
Major depression	CA	PRSC	Collapsing	0.05	0.108	0.336	0.359	0.770	0.106	0.072	0.361	0.621

MAF, minor allele frequency; Fp1, Fp5 and VT, association tests using SCORE-Seq; Collapsing, association test using ARIEL; EA, EAu, AA, CA and data set names refer to Table 1. Significant P-values are bold.