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. Author manuscript; available in PMC: 2012 Dec 17.
Published in final edited form as: J Pharmacol Exp Ther. 2012 Apr 16;342(1):169–176. doi: 10.1124/jpet.112.193847

Fig. 1.

Fig. 1

An ethyl acetate extract of S. officinalis inhibits mPGES-1 activity. Microsomal preparations of interleukin-1β-stimulated A549 cells were preincubated with an ethyl acetate extract of S. officinalis for 15 min at 4°C, and the reaction was started with 20 μM PGH2. After 1 min at 4°C, the reaction was terminated by using a stop solution containing FeCl2 and 11β-PGE2 (1 nmol) as internal standard. The concentration-response curve for the ethyl acetate extract of S. officinalis is shown. The 100% value corresponds to 246 ± 4 ng of PGE2. Data are given as mean + S.E. (n = 3-5). *, p < 0.05 or ***, p < 0.001 versus vehicle (DMSO) control, ANOVA + Tukey HSD post hoc tests.