Table 2.
Difference in adjusted mean change of KI score between interventions and placebo Group*.
| Time/weeks | CHM + PSY versus placebo | PSY versus placebo | CHM versus placebo | CHM + PSY versus PSY | CHM versus CHM + PSY | CHM versus PSY | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Difference in mean change (95% CI) | P value | P adjust | Difference in mean change (95% CI) | P value | P adjust | Difference in mean change (95% CI) | P value | P adjust | Difference in mean change (95% CI) | P value | P adjust | Difference in mean change (95% CI) | P value | P adjust | Difference in mean change (95% CI) | P value | P adjust | |
| 4 | −2.38 | 0.0109* | 1 | −1.49 | 0.1136 | 1 | −0.64 | 0.4857 | 1 | −0.89 | 0.3369 | 1 | 1.74 | 0.0567 | 1 | 0.84 | 0.3572 | 1 |
| (−5.88–1.12) | (−5–2.03) | (−4.09–2.81) | (−4.39–2.6) | (−1.68–5.16) | (−2.59–4.28) | |||||||||||||
| 8 | −3.08 | 0.0022* | 0.6026 | −1.99 | 0.0483* | 1 | −1.91 | 0.0532 | 1 | −1.09 | 0.2751 | 1 | 1.17 | 0.2337 | 1 | 0.08 | 0.9373 | 1 |
| (−6.85–0.69) | (−5.76–1.78) | (−5.61–1.79) | (−4.85–2.66) | (−2.52–4.86) | (−3.62–3.77) | |||||||||||||
| 12 | −3.12 | 0.0034* | 0.9401 | −2 | 0.0598 | 1 | −0.89 | 0.3927 | 1 | −1.12 | 0.2928 | 1 | 2.23 | 0.0333* | 1 | 1.11 | 0.2886 | 1 |
| (−7.11–0.87) | (−5.98–1.98) | (−4.8–3.02) | (−5.1–2.87) | (−1.69–6.14) | (−2.8–5.02) | |||||||||||||
| 16 | −3.27 | 0.0051* | 1 | −2.79 | 0.017* | 1 | −1.18 | 0.3011 | 1 | −0.48 | 0.6808 | 1 | 2.09 | 0.0678 | 1 | 1.61 | 0.1605 | 1 |
| (−7.65–1.1) | (−7.18–1.59) | (−5.48–3.11) | (−4.86–3.9) | (−2.2–6.38) | (−2.69–5.91) | |||||||||||||
| 20 | −3.29 | 0.0046* | 1 | −2.17 | 0.0621 | 1 | −0.74 | 0.5155 | 1 | −1.12 | 0.3338 | 1 | 2.55 | 0.0248* | 1 | 1.43 | 0.2089 | 1 |
| (−7.63–1.06) | (−6.52–2.19) | (−5–3.52) | (−5.47–3.23) | (−1.7–6.8) | (−2.83–5.68) | |||||||||||||
| 24 | −2.11 | 0.0585 | 1 | −0.69 | 0.535 | 1 | 0.18 | 0.8676 | 1 | −1.42 | 0.2041 | 1 | 2.3 | 0.0354* | 1 | 0.88 | 0.4227 | 1 |
| (−6.3–2.07) | (−4.89–3.5) | (−3.92–4.28) | (−5.61–2.77) | (−1.79–6.39) | (−3.22–4.98) | |||||||||||||
| Over all time points | −2.88 | 0.0021* | 0.0126* | −1.85 | 0.0476* | 0.2853 | −0.86 | 0.3463 | 1 | −1.02 | 0.2736 | 1 | 2.01 | 0.0279* | 0.1672 | 0.99 | 0.2797 | 1 |
| (−5.34–0.41) | (−4.32–0.62) | (−3.29–1.56) | (−3.48–1.44) | (−0.4–4.43) | (−1.43–3.41) | |||||||||||||
*P < 0.05.
*All analyses were conducted on the data adjusted for age (continuous), body mass index (kg/m2, continuous), menopausal status (menopause transition versus postmenopausal). Estimates of difference in mean change from baseline versus placebo, along with P values and 95% CIs, from mixed-model analysis that used data from baseline and all follow-up time points (total, n = 424 for adjusted analyses). Bonferroni method was adopted for the P value adjustment in the multiple comparisons.