Table 1.
Probands (n = 2) | Carriers (n = 6) | Noncarriers (n = 17) | P Probands versus Noncarriers |
P Carriers versus Noncarriers |
|
---|---|---|---|---|---|
Demographic and Lifestyle Characteristics | |||||
Age (year) | 72.5 (15) | 39.5 (21) | 44.9 (13) | 0.010 | 0.46 |
Gender (% male) | 50 | 17 | 53 | 0.94b | 0.12b |
Body mass index (kg/m2) | 20.9 (1.0) | 25.5 (4.7) | 24.4 (2.4) | 0.063 | 0.49 |
Smoking, n (%) | 0 | 1 (17) | 5 (29) | 0.37b | 0.37b |
Alcohol use (U/week)a | 8 | 1 (0–9) | 4 (0–15) | 0.84 | 0.38 |
Diabetes mellitus type 2 (n) | 0 | 1 | 1 | - | - |
Hypertension (n) | 0 | 0 | 0 | - | - |
Cardiovascular events (n) | 1 | 0 | 0 | - | - |
Lipids and Lipoproteins | |||||
Total cholesterol (mg/dl) | 278 (38) | 241 (48) | 195 (38) | 0.010 | 0.026 |
LDL cholesterol (mg/dl) | 158 (14) | 156 (38) | 128 (37) | 0.27 | 0.12 |
HDL cholesterol (mg/dl) | 106 (22) | 63 (11) | 56 (12) | <0.001 | 0.21 |
Triglycerides (mg/dl)a | 82.3 | 80 (59–100) | 93 (72–114) | 0.35 | 0.064 |
Apolipoproteins and LCAT Activity | |||||
ApoB (mg/dl) | 105 (20) | 121 (26) | 110 (31) | 0.82 | 0.45 |
Apo A-I (mg/dl) | 220 (46) | 147 (10) | 135 (36) | 0.007 | 0.44 |
Apo A-II (mg/dl) | 23.6 (0.9) | 29.3 (5.2) | 29.4 (4.4) | 0.08 | 0.96 |
ApoE (mg/dl) | 2.2 (0.3) | 2.3 (0.7) | 3.19 (1.1) | 0.23 | 0.09 |
Apo C-II (mg/dl) | 3.8 (0.9) | 4.2 (4) | 4.05 (1.8) | 0.85 | 0.89 |
Apo C-III (mg/dl) | 9.6 (0.3) | 10.1 (2.5) | 10.3 (2.5) | 0.72 | 0.89 |
LCATc activity (cholesteryl ester/ml/hr) | 17.3 (0.42) | 17.7 (3.5) | 16.9 (1.3) | 0.73 | 0.26 |
Data are presented as mean (SD) unless otherwise specified.
Alcohol use and triglycerides are given as median (interquartile range) and were log-transformed prior to statistical analysis. P values were calculated using a t test unless indicated otherwise.
For gender and smoking, a chi-square test was used.
LCAT, lecithin cholesterol:acyltransferase.