(A) Matrix calcium, normalized for total protein, in Rankltg and WT SMCs treated with control vehicle, beta-glycerophosphate (BGP, 5 mM), forskolin (Fsk, 25μM) or inorganic phosphate (Pi, 3 mM) for 7 days. (B) Matrix calcium, normalized for total protein, in Rankltg and WT SMCs treated with inorganic phosphate (Pi, 3 mM), and/or levamisole (Leva, 100 μM) for 10 days. (C) Matrix calcium, normalized for total protein, in Rankltg and WT SMCs treated with forskolin (Fsk, 25 μM) and/or levamisole (Lev, 100 μM) for 13 days. **p = 0.05; *p < 0.05; §p < 0.01; #p < 0.001.