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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Hypertension. 2012 Nov 5;60(6):1552–1559. doi: 10.1161/HYPERTENSIONAHA.112.202127

Figure 3. Structural biology.

Figure 3

(A) Molecular modeling of W-T and R-I peptides. The structures were created in ChemDraw and the inversion of chirality was achieved in Chem3D, followed by energy minimization (MM2 force field).

(B) Circular Dichroism (CD) spectroscopy of W-T vs. R-I synthetic catestatin regions from human CHGA. CD spectra of 21-amino acid catestatin peptides (hCgA352-372) at 0.125 mg/ml in 98% 2,2,2-trifluoroethanol were taken over 190–260 nm.