Table 3.
In Vitro Data of antimicrobial activities
| Compound |
C. albicans ATCC 90028 (μM) |
C. neoformans ATCC 90113 (μM) |
A. fumigatus ATCC 90906 (μM) |
M. intracellulare ATCC 23068 (μM) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| IC50 | MIC | MFC | IC50 | MIC | MFC | IC50 | MIC | MFC | IC50 | MIC | MBC | |
| 1 | 3.02 ± 0.04 | 10 | 20 | 1.53 ± 0.38 | 5 | 5 | 3.21 ± 0.05 | 10 | 20 | >20 | >20 | >20 |
| 2 | 3.64± 0.31 | 10 | 20 | 0.95± 0.15 | 5 | 10 | 3.09± 0.05 | 10 | 10 | >20 | >20 | >20 |
| 4 | 5.76± 0.27 | 20 | >20 | 1.73 ± 0.15 | 5 | 10 | 5.00 ± 0.74 | 10 | 20 | >20 | >20 | >20 |
| Amp B | 0.25 ± 0.04 | 0.625 | 1.25 | 0.79 ± 0.05 | 0.016 | 0.06 | 1.32 ± 0.06 | 2.5 | 2.5 | NT | NT | NT |
| Cipro | NT | NT | NT | NT | NT | NT | NT | NT | NT | 0.42 ± 0.07 | 1.0 | >1 |
NT= Not Tested
Amphotericin B and ciprofloxacin are used for positive control antifungal and antibacterial standards, respectively.
IC50 is the concentration that affords 50% inhibition of growth.
MIC (Minimum Inhibitory Concentration) is the lowest test concentration that allows no detectable growth.
MFC/MBC (Minimum Fungicidal/Bactericidal Concentration) is the lowest test concentration that kills 100% of the organism.