Table 3.

Molecular Signature of γ-Irradiation in Asexual Blood-Stage Plasmodium falciparum

Gene	Description	Microarraya	Real-Time PCRa	Biological Function
PFI1245c	Protein phosphatase β	2.06 ± 0.05	1.70 ± 0.28	Signal transduction
PFI1135c	OTU-like cysteine protease	−2.05 ± 0.10	−1.86 ± 0.10	Ubiquitin and proteasome
PFE1435c	Nucleolar preribosomal GTPase	−2.19 ± 0.12	−1.70 ± 0.06	Translation
PF13_0014	40S ribosomal protein S7	−2.20 ± 0.06	−2.04 ± 0.20	Translation
PFI0355c	AAA ATPase	−2.30 ± 0.04	−1.39 ± 0.13	Chaperone/protein stability
PFL1350w	RNA pseudouridylate synthase	−2.50 ± 0.07	−1.81 ± 0.28	Translation

Abbreviations: K, kilorad of γ-radiation delivered by a Cesium-137 source; PCR, polymerase chain reaction.

^a Performed in RNA samples prepared from asynchronous P. falciparum parasites irradiated at 60 K.