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. 2012 Nov 19;109(49):19977–19982. doi: 10.1073/pnas.1214337109

Fig. 1.

Fig. 1.

R7BP ablation augments GIRK activity. (A) GABA(B) receptor-evoked GIRK currents in wild-type and R7BP−/− hippocampal pyramidal neurons. Boxed inset highlights GIRK offset kinetics. (B) Quantification of GIRK current onset and offset kinetics in wild-type and R7BP−/− neurons. (C) R7BP ablation augments GIRK activation by a submaximal concentration of baclofen. (D) Quantification of GIRK currents elicited by a submaximal concentration of baclofen. (E) Rescue of GIRK current regulation by expression of R7BP in R7BP−/− neurons. Representative baclofen-evoked GIRK currents from R7BP−/− hippocampal pyramidal neurons that were untransfected or transfected with RFP-R7BP or RFP are shown. Arrows indicate current offset. (F) Quantification of GIRK current offset kinetics in transfected (RFP-R7BP or RFP) and untransfected R7BP−/− neurons. *P < 0.05, **P < 0.01, ***P < 0.0001.