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. 2012 Nov 19;109(49):20047–20052. doi: 10.1073/pnas.1213764109

Fig. 4.

Fig. 4.

HDAC4 reduces clonogenic potential and proliferation and increases apoptosis of B cells. (A) Quantitation of methylcellulose colony formation of OCI-Ly3 cells transduced with empty retrovirus (pMIG-Empty or ERV), pMIG-Bcl6 (or BRV), and pMIG-HDAC4 (or HRV). (B) MTS proliferation assay of HRV-, BRV-, or ERV-transduced OCI-Ly3 cells. (C) Apoptosis of human Bjab, OCI-Ly3, and mouse Wehi-231 (preB) cells transfected with pCMV6-Hdac4 or Empty vector alone. (D) Proliferation assay of OCI-Ly1 cells cotransfected with miR-155+Hdac4, Scr+Hdac4, miR-155 alone, or Hdac4 alone (Left) and Bjab cells transduced with HRV or ERV (Right). All experiments were repeated three or more times. *P < 0.05.