Fig. 4.

Maintenance-related deficits. Regions showing group differences during the maintenance phase of working memory (WM). Foci shown in panels A–D were identified using voxel-wise analyses (shown in table 2 middle panel), and foci shown in panels E–H were identified within the WM-related areas constrained space (shown in table 2 bottom panel). As in figure 3, all foci were identified using the assumed hemodynamic response function (HRF) analysis (see Methods), whereas time courses were extracted for each region using an unassumed HRF approach to facilitate visual inspection of group differences. The approximate relevant maintenance period of the time course is marked using the gray box. Time courses for control subjects are shown using circles whereas time courses for patients are shown using triangles.