Table 3.
Maternal Infection Before, During, and After Pregnancy in a Cohort of 1 115 752 Persons Born Between 1978 and 1998 of Whom 3722 Developed Schizophrenia During 11.9 Million Person Years of Follow-Up
IRRs (95% CIs) | ||||
Cases | Incidence Ratea | Basic Modelb | Adjusted Modelc | |
No infection during pregnancy, no infections before/after | 2488 | 2.80 | 1.00 (Reference) | 1.00 (Reference) |
No infection during pregnancy, 1 infection before/after | 625 | 3.77 | 1.32 (1.21–1.44) | 1.21 (1.11–1.32) |
Infection during pregnancy, no infections before/after | 68 | 3.05 | 1.09 (0.85–1.38) | 1.01 (0.79–1.28) |
Infection during pregnancy, at least one infection before/after | 34 | 6.36 | 2.06 (1.44–2.84) | 1.72 (1.20–2.38) |
No infection during pregnancy, at least 2 infections before/after | 507 | 4.87 | 1.62 (1.47–1.78) | 1.30 (1.18–1.44) |
Note: Abbreviation is explained in the first footnote to table 1.
The incidence rate measures the number of new cases per 10 000 person years.
Adjusted for calendar year, sex, and its interaction with age.
Further adjustment for family history of psychosis.