Table 2.

Summary of Methods of hiPSC Neural Differentiation Relevant to Schizophrenia

Species	Intended Cell Type	Purity	Method	Neuronal Characterization	Reference
Human	Cortical glutamatergic and GABAergic	Approaches 100% mixed cortical cells	Dual SMAD inhibition in the context of retinoids, followed by FGF2 treatment	Immunohistochemistry, gene expression, electrophysiology, and transplantation	Shi et al.,19 Mariani et al., 201218
Human	Midbrain dopaminergic neurons	>80%	Dual SMAD inhibition followed by SHH and WNT stimulation	Immunohistochemistry, gene expression, electrophysiology, and transplantation	Chambers et al., 200919; Kriks et al., 201130,31