Table 2.
Admission symptoms and signs for patients included in the analysis of the efficacy of artemether-lumefantrine (Coartem™) for the treatment of uncomplicated falciparum malaria in Laos
|
Symptoms and signs |
Total (n = 549) |
Age groups |
||
|---|---|---|---|---|
| Children (≤ 15 years) (n = 357) | Adults (> 15 years)(n = 192) | p-value | ||
| Headache* |
372/404 (92) |
189/212 (89) |
183/192 (95) |
0.02 |
| Chill |
498/549 (91) |
316/357 (88.5) |
182/192 (95) |
0.01 |
| Myalgia* |
230/404 (57) |
75/212 (35) |
155/192 (81) |
<0.001 |
| Weakness |
523/549 (95) |
337/357 (94) |
186/192 (97) |
0.19 |
| Dizziness* |
299/404 (74) |
150/212 (71) |
149/192 (78) |
0.11 |
| Vertigo* |
112/404 (28) |
59/212 (28) |
53/192 (28) |
0.96 |
| Tinnitus * |
83/404 (20.5) |
24/212 (11) |
59/192 (31) |
<0.001 |
| Anorexia |
490/549 (89) |
323/357 (90) |
167/192 (87) |
0.20 |
| Nausea* |
268/405 (66) |
158/213 (74) |
110/192 (57) |
<0.001 |
| Vomiting |
296/549 (54) |
211/357 (59) |
85/192 (44) |
0.001 |
| Abdominal pain* |
110/411 (27) |
59/219 (27) |
51/192 (26.5) |
0.93 |
| Diarrhoea |
111/548 (20) |
72/356 (20) |
39/192 (20) |
0.98 |
| Insomnia* |
313/549 (57) |
203/357 (57) |
110/192 (57) |
0.92 |
| Nightmare* |
38/404 (9) |
17/212 (8) |
21/192 (11) |
0.31 |
| Palpitation* |
173/404 (43) |
62/212 (29) |
111/192 (58) |
<0.001 |
| Dyspnea* |
141/546 (26) |
76/354 (21) |
65/192 (34) |
0.002 |
| Cough |
125/549 (23) |
76/357 (21) |
49/192 (25.5) |
0.25 |
| Sore throat* |
49/410 (12) |
29/218 (13) |
20/192 (10) |
0.36 |
| Irritable |
10/547 (2) |
10/355 (3) |
0 |
0.01 |
| Rash |
1/549 (0.2) |
1/357 (0.3) |
0 |
1.00 |
| Urticaria |
4/549 (0.7) |
2/357 (0.6) |
2/192 (1) |
0.61 |
| Itch |
4/549 (0.7) |
2/357 (0.6) |
2/192 (1) |
0.61 |
| Chest abnormality** | 2/549 (0.4) | 1/357 (0.3) | 1/192 (0.5) | 1.00 |
NOTE. Data are shown as number (%).
* Only children aged ≥ 4 years were asked about these symptoms.
** Chest abnormality: crepitation, rhonchi.