Table 2.
SNP pairs detected through analysis of pathway, network and eSNPs
| SNP1 | chr | gene | P-value (snp1) | SNP2 | Chr | gene | P-value (snp2) | P-value (interaction) | Correlation | Analysis |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1130199 | 17 | CDC6 RARA |
1.5 × 10-5 | rs4253764 | 22 | PPARA | 1.3 × 10-7 | 7.0 × 10-11 | 0.35 | Pathway |
| rs2490429 | 1 | ATF6 OLFML2B |
2.2 × 10-7 | rs41433646 | 12 | RBM19 | 2.2 × 10-2 | 2.9 × 10-11 | 0.15 | Subnetwork |
| rs4253764 | 22 | PPARA | 1.3 × 10-7 | rs41433646 | 12 | RBM19 | 2.2 × 10-2 | 9.9 × 10-10 | 0.33 | Subnetwork |
| Rs12517663 | 5 | - | 5.5 × 10-1 | Rs3751726 | 16 | KLHDC4 | 2.9 × 10-1 | 9.6 × 10-10 | 0.09 | Esnp |
chr stands for chromosome; Correlation: correlation coefficient between two SNPs.