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. 2012 Oct 10;5(1):11–16. doi: 10.3892/etm.2012.739

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Copyright © 2013, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Enhancement of cetuximab-induced apoptosis by ultrasound (US). Induction of apoptosis was assessed by FITC-Annexin V/PI assay 24 h after treatment in (A) HSC-3 cells and (B) HSC-4 cells. The data indicate the mean ± standard deviation (SD) and values are representative of more than three different experiments performed. Values (^*) assessed as synergy by two-way factorial analysis of variance (ANOVA); ^*P<0.01. Significantly more apoptosis was observed in the COMB group compared with the other groups. CNTRL, non-treated; CETU, cetuximab-treated; UST, ultrasound-treated; COMB, combination of cetuximab and US-treated.