Table I.
Clinicopathological characteristics of 159 gastric cancer patients according to PTEN expression profile.
| Characteristics | Total no. | Cytoplasmic PTEN negative, n=98 (62%) | P value | Nuclear PTEN negative, n=119 (75%) | P value | Total PTEN negative, n=77 (48%) | P value | Downregulated PTEN expression, n=113 (71%) | P value |
|---|---|---|---|---|---|---|---|---|---|
| Gender | |||||||||
| M | 112 | 70 (63%) | 0.725 | 84 (75%) | 1 | 54 (48%) | 1 | 82 (78%) | 0.025 |
| F | 47 | 28 (60%) | 35 (74%) | 23 (49%) | 25 (58%) | ||||
| Age (years) | |||||||||
| Median | 65 | 65 | 67 | 65 | 65 | ||||
| Range | 34–84 | 41–83 | 41–84 | 41–83 | 41–84 | ||||
| Histological grade | |||||||||
| I | 2 | 0 (0%) | 0.016 | 2 (100%) | 0.287 | 0 (0%) | 0.244 | 1 (50%) | 0.717 |
| II | 40 | 19 (48%) | 33 (83%) | 17 (43%) | 28 (70%) | ||||
| III | 117 | 79 (68%) | 84 (72%) | 60 (51%) | 80 (73%) | ||||
| AJCC stage | |||||||||
| I | 13 | 5 (38%) | 0.271 | 6 (46%) | 0.051 | 1 (8%) | 0.012 | 4 (33%) | 0.018 |
| II | 49 | 33 (67%) | 39 (80%) | 0.013a | 29 (59%) | 0.002a | 36 (77%) | 0.004a | |
| III | 86 | 54 (63%) | 64 (74%) | 42 (49%) | 60 (74%) | ||||
| IV | 11 | 6 (55%) | 10 (91%) | 5 (45%) | 9 (82%) | ||||
| Depth of invasion | |||||||||
| T1 | 11 | 7 (64%) | 0.897 | 7 (64%) | 0.828 | 4 (36%) | 0.851 | 6 (60%) | 0.578 |
| T2 | 14 | 8 (57%) | 11 (79%) | 7 (50%) | 10 (71%) | ||||
| T3 | 104 | 66 (63%) | 78 (75%) | 52 (50%) | 71 (71%) | ||||
| T4 | 30 | 17 (57%) | 23 (77%) | 14 (47%) | 22 (81%) | ||||
| Lymph node metastasis | |||||||||
| N0 | 36 | 20 (56%) | 0.836 | 27 (75%) | 0.632 | 17 (47%) | 0.841 | 22 (65%) | 0.213 |
| N1 | 26 | 16 (62%) | 17 (65%) | 11 (42%) | 17 (68%) | ||||
| N2 | 49 | 32 (65%) | 37 (76%) | 26 (53%) | 40 (83%) | ||||
| N3 | 48 | 30 (63%) | 38 (79%) | 23 (48%) | 30 (68%) | ||||
| Distant metastasis | |||||||||
| M0 | 148 | 92 (62%) | 0.75 | 109 (74%) | 0.29 | 72 (49%) | 1 | 100 (71%) | 0.728 |
| M1 | 11 | 6 (55%) | 10 (91%) | 5 (45%) | 9 (82%) |
a
AJCC stage I vs. stages II–IV. M, male; F, female; AJCC, American Joint Committee on Cancer.