Table II.
Receiver operating characteristic curve analysis of PTEN expression.
| Optimal cut-off point
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| PTEN expression pattern | AUC (95% CI) | P-value | Sensitivity (%) | Specificity (%) | +PV (%) | −PV (%) | +LR | +LR | Diagnostic accuracy (%) |
| Cytoplasmic | 0.865 (0.822–0.901) | <0.0001 | 76.1 | 87.4 | 85.9 | 77.4 | 6.05 | 0.27 | 85.9 |
| Nuclear | 0.516 (0.459–0.573) | 0.617 | 76.7 | 29.1 | 53.3 | 54.3 | 1.08 | 0.80 | 53.3 |
| Total | 0.829 (0.783–0.870) | <0.0001 | 64.2 | 88.7 | 85.7 | 70.2 | 5.7 | 0.40 | 85.7 |
The optimal cut-off point was defined using MedCalc software. AUC, area under the curve; CI, confidence interval; PV, predictive value; LR, likelihood ratio.