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. 2012 Sep 25;31(1):80. doi: 10.1186/1756-9966-31-80

Table 3.

Multivariate statistic of gender, age, histology, smoking status, treat line, EGFR mutation and SFRP5 methylation for objective response rate (ORR) and disease control rate (DCR)

Variable Objective response rate (ORR)
Disease control rate (DCR)
Univariate
Multivariate
Univariate
Multivariate
P value P value Hazard ratio (95% CI) P value P value Hazard ratio (95% CI)
Gender (male / female)
0.188
0.881
0.926 (0.337-2.542)
0.001
0.115
2.117 (0.834-5.734)
Age (≤65 / >65)
0.351
0.078
2.295 (0.912-5.772)
0.291
0.791
1.110 (0.515-2.393)
Histology (adenocarcinoma / nonadenocarcinoma)
0.002
0.006
6.680 (1.712-26.057)
0.049
0.244
1.663 (0.707-3.915)
Line Treatment (first line / not-first line)
0.016
0.078
2.184 (0.917-5.200)
0.940
0.491
0.756 (0.341-1.678)
Smoking Status (smoker / nonsmoker)
0.016
0.262
0.526 (0.171-1.617)
0.001
0.188
0.524 (0.200-1.371)
EGFR Mutation (wide type / mutation)
<0.0001
<0.0001
7.695 (2.895-20.454)
<0.0001
0.002
3.255 (1.540-6.881)
SFRP5 Methylation (methylated / unmethylated) 0.222 0.650 0.734 (0.193-2.788) 0.04 0.106 0.434 (0.158-1.193)