Table 3.
Multivariate statistic of gender, age, histology, smoking status, treat line, EGFR mutation and SFRP5 methylation for objective response rate (ORR) and disease control rate (DCR)
| Variable |
Objective response rate (ORR) |
Disease control rate (DCR) |
||||
|---|---|---|---|---|---|---|
|
Univariate |
Multivariate |
Univariate |
Multivariate |
|||
| P value | P value | Hazard ratio (95% CI) | P value | P value | Hazard ratio (95% CI) | |
|
Gender (male / female) |
0.188 |
0.881 |
0.926 (0.337-2.542) |
0.001 |
0.115 |
2.117 (0.834-5.734) |
|
Age (≤65 / >65) |
0.351 |
0.078 |
2.295 (0.912-5.772) |
0.291 |
0.791 |
1.110 (0.515-2.393) |
|
Histology (adenocarcinoma / nonadenocarcinoma) |
0.002 |
0.006 |
6.680 (1.712-26.057) |
0.049 |
0.244 |
1.663 (0.707-3.915) |
|
Line Treatment (first line / not-first line) |
0.016 |
0.078 |
2.184 (0.917-5.200) |
0.940 |
0.491 |
0.756 (0.341-1.678) |
|
Smoking Status (smoker / nonsmoker) |
0.016 |
0.262 |
0.526 (0.171-1.617) |
0.001 |
0.188 |
0.524 (0.200-1.371) |
|
EGFR Mutation (wide type / mutation) |
<0.0001 |
<0.0001 |
7.695 (2.895-20.454) |
<0.0001 |
0.002 |
3.255 (1.540-6.881) |
| SFRP5 Methylation (methylated / unmethylated) | 0.222 | 0.650 | 0.734 (0.193-2.788) | 0.04 | 0.106 | 0.434 (0.158-1.193) |