Table 4.
Cox proportional hazard regression analysis of gender, age, histology, smoking status, EGFR mutation, WIF1 methylation and SFRP5 methylation for progression-free survival (PFS)
| Variable | P value | Hazard ratio (95% CI) |
|---|---|---|
|
Smoking Status |
0.986 |
1.004 |
| (smokers/nonsmokers) |
|
(0.615-1.640) |
|
Histology |
0.689 |
0.915 |
| (adenocarcinoma/Nonadenocarcinoma) |
|
(0.592-1.414) |
|
Gender |
0.006 |
0.516 |
| (male/female) |
|
(0.322-0.826) |
|
Age |
0.456 |
0.858 |
| (<65/>65) |
|
(0.575-1.282) |
|
Lines of Treatment |
0.302 |
0.807 |
| (first line/non-first line) |
|
(0.537-1.213) |
|
EGFR Mutation |
0.024 |
0.656 |
| (mutation/wide type) |
|
(0.455-0.945) |
|
SFRP5 Methylation |
0.008 |
2.165 |
| (methylated/unmethylated) |
|
(1.226-3.823) |
|
WIF1 Methylation |
0.224 |
1.804 |
| (methylated/unmethylated) | (0.697-4.674) |